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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-Arcyriaflavin A
Arcyriaflavin A

Chemical Structure : Arcyriaflavin A

CAS No.: 118458-54-1

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Arcyriaflavin A

货号: PC-23981Not For Human Use, Lab Use Only.

Arcyriaflavin A is a potent inhibitor of the cyclin D1/CDK4 complex with IC50 of 140 nM, also inhibits CaMKII with IC50 of 25 nM, suppresses tumor growth, migration, and invasion of metastatic melanoma cells.

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Arcyriaflavin A is a potent inhibitor of the cyclin D1/CDK4 complex with IC50 of 140 nM, also inhibits CaMKII with IC50 of 25 nM, suppresses tumor growth, migration, and invasion of metastatic melanoma cells.

物理化学性质&存储条件

分子量 325.33
分子式 C20H11N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12,13-dihydro-

参考文献

1. P A Horton, et al. Experientia. 1994 Sep 15;50(9):843-5.

2. Sanchez-Martinez C, et al. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3835-9.

3. Kim D, et al. Cancer Cell Int. 2025 Feb 13;25(1):42.

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