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首页-抗体和重组蛋白-Biosimilar Antibody-Aprutumab
Aprutumab

Chemical Structure : Aprutumab

CAS No.: 1634620-63-5

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Aprutumab (Anti-human FGFR human IgG1-Kappa; BAY-1179470)

货号: PC-Ab1050Not For Human Use, Lab Use Only.

Aprutumab Ixadotin (BAY 1187982) is an antibody-drug conjugate (ADC) directed against the fibroblast growth factor receptor type 2 (FGFR2) and conjugated to an as of yet unidentified toxin, with potential antineoplastic activity. Aprutumab is a fully human FGFR2 monoclonal antibody (mAb BAY 1179470), which binds to the FGFR2 isoforms FGFR2-IIIb and FGFR2-IIIc, conjugated through a noncleavable linker to a novel derivative of the microtubule-disrupting cytotoxic drug auristatin (FGFR2-ADC)..

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10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Aprutumab Ixadotin (BAY 1187982) is an antibody-drug conjugate (ADC) directed against the fibroblast growth factor receptor type 2 (FGFR2) and conjugated to an as of yet unidentified toxin, with potential antineoplastic activity. Aprutumab is a fully human FGFR2 monoclonal antibody (mAb BAY 1179470), which binds to the FGFR2 isoforms FGFR2-IIIb and FGFR2-IIIc, conjugated through a noncleavable linker to a novel derivative of the microtubule-disrupting cytotoxic drug auristatin (FGFR2-ADC).

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Aprutumab; BAY-1179470; BAY 1179470; Aprutumab ixadotin; BAY 1187982; 1634620-63-5; Fibroblast growth factor receptor 2; FGFR2.

参考文献

1. 1, Sommer A, et al. Cancer Res. 2016 Nov 1;76(21):6331-6339. 2, Kim SB, et al. Target Oncol. 2019 Oct;14(5):591-601.

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