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首页-小分子抑制剂&激动剂-Others-Other Targets-Aprotinin
Aprotinin

Chemical Structure : Aprotinin

CAS No.: 9087-70-1

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Aprotinin

货号: PC-38253Not For Human Use, Lab Use Only.

Aprotinin is a single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities, inhibits trypsin and chymotrypsin with Ki of 0.06 pM and 9 nM respectively.

规格 价格 库存 数量
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg ￥2980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Aprotinin is a single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities, inhibits trypsin and chymotrypsin with Ki of 0.06 pM and 9 nM respectively.
As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation.
Aprotinin also inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis.

物理化学性质&存储条件

分子量 6511
分子式 C284H432N84O79S7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO 10 mM in H2O
Chemical Name/SMILES

Arg-Pro-Asp-Phe-Cys-Leu-Glu-Pro-Pro-Tyr-Thr-Gly-Pro-Cys-Lys-Ala-Arg-Ile-Ile-Arg-Tyr-Phe-Tyr-Asn-Ala-Lys-Ala-Gly-Leu-Cys-Gln-Thr-Phe-Val-Tyr-Gly-Gly-Cys-Arg-Ala-Lys-Arg-Asn-Asn-Phe-Lys-Ser-Ala-Glu-Asp-Cys-Met-Arg-Thr-Cys-Gly-Gly-Ala(Disulfide bridge: Cys5-Cys55,Cys14-Cys38,Cys30-Cys51)

参考文献

1. Fritz H, et al. Arzneimittelforschung. 1983;33(4):479-94.
2. Sabbagh MJ, et al. J Cardiovasc Pharmacol. 2008 Oct;52(4):355-62.

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