Aprocitentan (ACT132577) | Endothelin receptor antagonist

Chemical Structure : Aprocitentan

CAS No.: 1103522-45-7

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Aprocitentan (ACT-132577, ACT132577)

货号: PC-60030Not For Human Use, Lab Use Only.

Aprocitentan (ACT132577) is the major and pharmacologically active metabolite of Macitentan, an orally active, dual endothelin receptor antagonist with IC50s of 3.4 nM and 987 nM for ETA/ETB receptor respectively, inhibits ET-1 and ET-2-induced contractions in functional assays.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

Aprocitentan (ACT132577) is the major and pharmacologically active metabolite of Macitentan, an orally active, dual endothelin receptor antagonist with IC50s of 3.4 nM and 987 nM for ETA/ETB receptor respectively, inhibits ET-1 and ET-2-induced contractions in functional assays.

物理化学性质&存储条件

分子量	546.194
分子式	C16H14Br2N6O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]sulfuric diamide

参考文献

1. Iglarz M, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):736-45.

2. Kummer O, et al. Eur J Pharm Sci. 2009 Nov 5;38(4):384-8.

3. Sidharta PN, et al. Eur J Clin Pharmacol. 2011 Oct;67(10):977-84.

Aprocitentan (ACT-132577, ACT132577)

生物&药学活性

物理化学性质&存储条件

参考文献

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Aprocitentan (ACT-132577, ACT132577)

生物&药学活性

物理化学性质&存储条件

参考文献

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