Aprepitant |CAS:170729-80-3 Probechem Biochemicals

Chemical Structure : Aprepitant

CAS No.: 170729-80-3

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Aprepitant (MK-0869;MK-869;L-754030)

货号: PC-42185Not For Human Use, Lab Use Only.

Aprepitant (MK-0869) is a potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM.

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25 mg	￥1180	In stock
50 mg	￥1780	In stock
100 mg	￥2780	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Aprepitant (MK-0869) is a potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM.
Aprepitant (MK-0869) blocks NK-1 agonist-induced foot tapping response in gerbils and shows antiemetic actions in the ferret against cisplatin challenge.
Aprepitant (MK-0869) has the potentiation for the treatment of peripheral pain, migraine, chemotherapy-induced emesis, and various psychiatric disorders.

物理化学性质&存储条件

分子量	534.4266
分子式	C23H21F7N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-

参考文献

1. Kramer MS, et al. Science. 1998 Sep 11;281(5383):1640-5.

2. Hale JJ, et al. J Med Chem. 1998 Nov 5;41(23):4607-14.

3. Tattersall FD, et al. Neuropharmacology. 2000 Feb 14;39(4):652-63.

Aprepitant (MK-0869;MK-869;L-754030)

生物&药学活性

物理化学性质&存储条件

参考文献

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Aprepitant (MK-0869;MK-869;L-754030)

生物&药学活性

物理化学性质&存储条件

参考文献

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