Apoxidole-1 | IDO1 inhibitor | Probechem Biochemicals

Chemical Structure : Apoxidole-1

加入收藏

Apoxidole-1 (Apoxidole 1)

货号: PC-20021Not For Human Use, Lab Use Only.

Apoxidole-1 is a potent, selective type IV inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), Apoxidole-1 reduces cellular kynurenine (Kyn) levels with IC50 of 46.7 in HeLa cells, but does not inhibit IDO1 expression.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Apoxidole-1 is a potent, selective type IV inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), Apoxidole-1 reduces cellular kynurenine (Kyn) levels with IC50 of 46.7 in HeLa cells, but does not inhibit IDO1 expression.
Apoxidole-1 targets apo-IDO1 and interferes with heme binding, induces unique amino acid positioning as revealed by crystal structure analysis.
Apoxidole-1 does not inhibit TDO or IDO2.
Apoxidole-1 directly binds to IDO1 with an apparent dissociation constant (KD,app) of 1.1 uM, ITC KD of 20.7 nM.
Apoxidole-1 is inactive in the IDO1 enzymatic assay at 25°C, after preincubation at 37°C Apoxidole-1 dose-dependently decreases IDO1 activity.

物理化学性质&存储条件

分子量	596.70
分子式	C31H36N2O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3,6-Pyridinetricarboxylic acid, 1,2,5,6-tetrahydro-6-(1-methyl-1H-indol-2-yl)-1-[(4-methylphenyl)sulfonyl]-, 2-(1,1-dimethylethyl) 3-ethyl 6-methyl ester, (2S,6R)-

参考文献

1. Caitlin Davies, et al. Angew Chem Int Ed Engl. 2022 Oct 4;61(40):e202209374.

Apoxidole-1 (Apoxidole 1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Apoxidole-1 (Apoxidole 1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.