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Apostatin-1

Chemical Structure : Apostatin-1

CAS No.: 2559703-06-7

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Apostatin-1 (Apostatin 1)

货号: PC-38288Not For Human Use, Lab Use Only.

Apostatin-1 is a small molecule that binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N).

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10 mg ￥1980 In stock
25 mg ￥2980 In stock
100 mg ￥5980 In stock
200 mg Get quote
1 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Apostatin-1 is a small molecule that binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N).
TRADD-N interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ubiquitination of RIPK1 and beclin 1.
Apostatin-1 effectively induced autophagy and the degradation of long-lived proteins.
Inhibition of TRADD by ICCB-19 or Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin.

物理化学性质&存储条件

分子量 345.502
分子式 C19H27N3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-Cycloheptyl-2-[(1-methyl-4,5-dihydro-1H-imidazol-2-yl)sulfanyl]-2-phenylacetamide

参考文献

1. Daichao Xu, et al. Nature. 2020 Nov;587(7832):133-138.

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