Apoptozole

Chemical Structure : Apoptozole

CAS No.: 1054543-47-3

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货号: PC-73133Not For Human Use, Lab Use Only.

Apoptozole is a inhibits the ATPase activity of HSP70 and Hsc70 by binding to ATPase domain, induces an array of apoptotic phenotypes in cancer cells.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2280	In stock
100 mg		Get quote

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生物&药学活性

Apoptozole is a inhibits the ATPase activity of HSP70 and Hsc70 by binding to ATPase domain, induces an array of apoptotic phenotypes in cancer cells.
Apoptozole binds HSP70 but not other types of heat shock proteins including HSP40, HSP60, and HSP90.
Apoptozole induces cancer cell death via caspase-dependent apoptosis by disrupting the interaction of HSP70 with APAF-1.
Apoptozole treatment retards tumor growth in a xenograft mouse model without affecting mouse viability.
Apoptozole also enhances immune responses to administered antigens.
Apoptozole also has high cellular potency to promote membrane trafficking of mutant CFTR and its chloride channel activity in cystic fibrosis cells.

物理化学性质&存储条件

分子量	625.571
分子式	C33H25F6N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((2-(3,5-Bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl)methyl)benzamide

参考文献

1. Park SH, et al. Sci Rep. 2017 Jun 14;7(1):3537.

2. Cho HJ, et al. J Am Chem Soc. 2011 Dec 21;133(50):20267-76.

3. Baek KH, et al. Sci Rep. 2015 Dec 3;5:17642.

4. Ko SK, et al. Chem Biol. 2015 Mar 19;22(3):391-403.

Apoptozole

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