Apomine | HMGCR inhibitor | Probechem Biochemicals

Chemical Structure : Apomine

CAS No.: 126411-13-0

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Apomine (SR45023A, SR 9223i, SK&F-99085)

货号: PC-49778Not For Human Use, Lab Use Only.

Apomine (SR-45023A) is an oral biphosphonate antineoplastic compound inhibiting HMG-CoA reductase, induces HMG-CoA reductase degradation with EC50 of 0.88 uM.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

Apomine (SR-45023A) is an oral biphosphonate antineoplastic compound inhibiting HMG-CoA reductase, induces HMG-CoA reductase degradation with EC50 of 0.88 uM.
Apomine (SR-45023A) inhibited growth of a wide variety of tumor cell line with IC50 of 5-14 uM.
Apomine (SR-45023A) triggered apoptosis in HL60 cells in less than 2 h, induced caspase-3 activity at concentrations similar to their IC(50) values for cell proliferation.
Apomine (SR-45023A) selectively inhibits cell proliferation and induces tumor cell apoptosis through the farnesoid X receptor.

物理化学性质&存储条件

分子量	562.66
分子式	C28H52O7P2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tetraisopropyl (2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethane-1,1-diyl)bis(phosphonate)

参考文献

1. Flach J, et al. Biochem Biophys Res Commun. 2000 Apr 2;270(1):240-6.

2. Alberts DS, et al. Clin Cancer Res. 2001 May;7(5):1246-50.

3. Toyota Y, et al. Bioorg Med Chem. 2020 Jul 15;28(14):115576.

Apomine (SR45023A, SR 9223i, SK&F-99085)

生物&药学活性

物理化学性质&存储条件

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Apomine (SR45023A, SR 9223i, SK&F-99085)

生物&药学活性

物理化学性质&存储条件

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