Aplaviroc |CAS:461443-59-4 Probechem Biochemicals

Chemical Structure : Aplaviroc

加入收藏

Aplaviroc (AK-602;GW 873140;ONO-4128;GSK-873140)

货号: PC-61968Not For Human Use, Lab Use Only.

Aplaviroc (GSK-873140, GW 873140, AK-602, ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor with pKb of 8.6.

规格	价格	库存	数量
5 mg		Get quote
10 mg		Get quote
25 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Aplaviroc (GSK-873140, GW 873140, AK-602, ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor with pKb of 8.6.
Aplaviroc blocks the calcium response effects of CCR5 activation by CCL5, and potently blocks in vitro the infection of R5-tropic HIV-1 (R5-HIV-1) at subnanomolar IC50.

物理化学性质&存储条件

分子量	577.722
分子式	C33H43N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undecan-9-yl]methyl]phenoxy]benzoic acid

参考文献

1. Watson C, et al. Mol Pharmacol. 2005 Apr;67(4):1268-82.

2. Lalezari J, et al. AIDS. 2005 Sep 23;19(14):1443-8.

3. Adkison KK, et al. Antimicrob Agents Chemother. 2005 Jul;49(7):2802-6.

4. Nakata H, et al. Antimicrob Agents Chemother. 2008 Jun;52(6):2111-9.

Aplaviroc (AK-602;GW 873140;ONO-4128;GSK-873140)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Aplaviroc (AK-602;GW 873140;ONO-4128;GSK-873140)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.