Aplaviroc (GSK-873140) | CCR5 antagonist | Probechem Biochemicals

Chemical Structure : Aplaviroc

CAS No.: 461443-59-4

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Aplaviroc (AK-602, GW 873140, ONO-4128, GSK-873140)

货号: PC-61968Not For Human Use, Lab Use Only.

Aplaviroc (GSK-873140, GW 873140, AK-602, ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor with pKb of 8.6.

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10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

Aplaviroc (GSK-873140, GW 873140, AK-602, ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor with pKb of 8.6.
Aplaviroc blocks the calcium response effects of CCR5 activation by CCL5, and potently blocks in vitro the infection of R5-tropic HIV-1 (R5-HIV-1) at subnanomolar IC50.

物理化学性质&存储条件

分子量	577.722
分子式	C33H43N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undecan-9-yl]methyl]phenoxy]benzoic acid

参考文献

1. Watson C, et al. Mol Pharmacol. 2005 Apr;67(4):1268-82.

2. Lalezari J, et al. AIDS. 2005 Sep 23;19(14):1443-8.

3. Adkison KK, et al. Antimicrob Agents Chemother. 2005 Jul;49(7):2802-6.

4. Nakata H, et al. Antimicrob Agents Chemother. 2008 Jun;52(6):2111-9.

Aplaviroc (AK-602, GW 873140, ONO-4128, GSK-873140)

生物&药学活性

物理化学性质&存储条件

参考文献

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Aplaviroc (AK-602, GW 873140, ONO-4128, GSK-873140)

生物&药学活性

物理化学性质&存储条件

参考文献

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