Apelin receptor agonist MM07 | APLNR agonist | Probechem Biochemicals

Chemical Structure : Apelin receptor agonist MM07

CAS No.: 1876450-21-3

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Apelin receptor agonist MM07 (MM 07)

货号: PC-26100Not For Human Use, Lab Use Only.

Apelin receptor agonist MM07 is a potent G-protein-biased peptide agonist of apelin receptor (APLNR, APJ) with KD of 300 nM in CHO-K1 cells and 172 nM in human heart.

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10 mg	￥1880	In stock
25 mg	￥3280	In stock
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生物&药学活性

Apelin receptor agonist MM07 is a potent G-protein-biased peptide agonist of apelin receptor (APLNR, APJ) with KD of 300 nM in CHO-K1 cells and 172 nM in human heart.
MM07 (10-100 nM) caused a dose-dependent increase in cardiac output in rats.
MM07 preferentially stimulate the G-protein pathway, which could translate to improved efficacy in the clinic by selectively stimulating vasodilatation and inotropic actions but avoiding activating detrimental β-arrestin-dependent pathways.

物理化学性质&存储条件

分子量	1539.91
分子式	C67H106N22O14S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cys-Arg-Pro-Arg-Leu-Cys-His-Lys-Gly-Pro-Met-Pro-Phe (Disulfide bridge:Cys1-Cys6)

参考文献

1. Brame AL, et al. Hypertension. 2015 Apr;65(4):834-40.

Apelin receptor agonist MM07 (MM 07)

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物理化学性质&存储条件

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Apelin receptor agonist MM07 (MM 07)

生物&药学活性

物理化学性质&存储条件

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