Apararenone |CAS:945966-46-1 Probechem Biochemicals

Chemical Structure : Apararenone

CAS No.: 945966-46-1

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Apararenone (MT-3995;MT3995)

货号: PC-35937Not For Human Use, Lab Use Only.

Apararenone (MT-3995) is a highly selective and potent, nonsteroidal mineralocorticoid receptor (MR) antagonist with Ki of 104 nM, >360-fold selectivity over GR,AR,PR and ER receptors.

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10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

Apararenone (MT-3995) is a highly selective and potent, nonsteroidal mineralocorticoid receptor (MR) antagonist with Ki of 104 nM, >360-fold selectivity over GR,AR,PR and ER receptors.
Apararenone (MT-3995) exhibited a more potent antihypertensive and organ-protective activity than steroidal MRA eplerenone in a primary aldosteronism rat model obtained by infusing aldosterone in uninephrectomized rats.

物理化学性质&存储条件

分子量	364.391
分子式	C17H17FN2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)methanesulfonamide

参考文献

1. Kolkhof P, et al. Curr Opin Nephrol Hypertens. 2015 Sep;24(5):417-24.
2. Kolkhof P, et al. J Endocrinol. 2017 Jul;234(1):T125-T140.
3. Iijima T, et al. J Med Chem. 2022 Jun 2. doi: 10.1021/acs.jmedchem.2c00402.

Apararenone (MT-3995;MT3995)

生物&药学活性

物理化学性质&存储条件

参考文献

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Apararenone (MT-3995;MT3995)

生物&药学活性

物理化学性质&存储条件

参考文献

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