Apafant (WEB2086) | PAF antagonist | Probechem Biochemicals

Chemical Structure : Apafant

CAS No.: 105219-56-5

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Apafant (WEB2086, WEB-2086)

货号: PC-70045Not For Human Use, Lab Use Only.

Apafant (WEB2086) is a potent and specific antagonist of platelet activating factor (PAF) receptor that inhibits PAF-induced human platelet and neutrophil aggregation in vitro with IC50 of 0.17 and 0.36 uM, respectively.

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5 mg	￥1480	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
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生物&药学活性

Apafant (WEB2086) is a potent and specific antagonist of platelet activating factor (PAF) receptor that inhibits PAF-induced human platelet and neutrophil aggregation in vitro with IC50 of 0.17 and 0.36 uM, respectively.
Apafant (WEB2086) reverses or abolishes the bronchoconstriction, hypotension, thrombocytopenia and leukopenia induced by PAF-acether at 0.1-1 mg/kg in guinea-pigs.
Apafant (WEB2086) also markedly decreases the bronchoconstriction and leukopenia induced by 100 ug/kg antigen in mepyramine.

物理化学性质&存储条件

分子量	455.961
分子式	C22H22N5O2SCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl)-1-morpholinopropan-1-one

参考文献

1. Casals-Stenzel J, et al. J Pharmacol Exp Ther. 1987 Jun;241(3):974-81.

2. Casals-Stenzel J, et al. Br J Pharmacol. 1987 Aug;91(4):799-802.

Apafant (WEB2086, WEB-2086)

生物&药学活性

物理化学性质&存储条件

参考文献

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Apafant (WEB2086, WEB-2086)

生物&药学活性

物理化学性质&存储条件

参考文献

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