Annamycin | Topo II inhibitor | Probechem Biochemicals

Chemical Structure : Annamycin

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Annamycin (Naxtarubicin)

货号: PC-24967Not For Human Use, Lab Use Only.

Annamycin (Naxtarubicin) is a highly lipophilic anthracycline antibiotic that has been shown to circumvent MDR-1 both in vitro and in vivo, intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as inhibiting RNA and protein synthesis.

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生物&药学活性

物理化学性质&存储条件

分子量	640.38
分子式	C26H25IO11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7S,9S)-7-(((2R,3R,4R,5R,6S)-4,5-dihydroxy-3-iodo-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-7,8,9,10-tetrahydrotetracene-5,12-dione

参考文献

1. Wetzler M, et al. Clin Lymphoma Myeloma Leuk. 2013 Aug;13(4):430-4.

2. Trevino AV, et al. Mol Cancer Ther. 2004 Nov;3(11):1403-10.

3. Perez-Soler R, et al. Int J Cancer. 1997 Mar 28;71(1):35-41.

Annamycin (Naxtarubicin)

生物&药学活性

物理化学性质&存储条件

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Annamycin (Naxtarubicin)

生物&药学活性

物理化学性质&存储条件

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