Anguizole | HCV NS4B inhibitor | Probechem Biochemicals

Chemical Structure : Anguizole

CAS No.: 442666-98-0

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Anguizole (HCV NS4B inhibitor)

货号: PC-43491Not For Human Use, Lab Use Only.

Anguizole is a HCV NS4B inhibitor targeting second amphipathic helix of NS4B (NS4B-AH2), blocks genotype 1b HCV replication with EC50 of 310 nM.

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生物&药学活性

Anguizole is a HCV NS4B inhibitor targeting second amphipathic helix of NS4B (NS4B-AH2), blocks genotype 1b HCV replication with EC50 of 310 nM.
Anguizole disrupts NS4B-AH2-mediated biological functions of NS4B, NS4B's dimerization/multimerization, its proper subcellular localization, as well as its interaction with NS5A.

物理化学性质&存储条件

分子量	408.81
分子式	C17H11ClF2N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrazolo[1,5-a]pyrimidine-2-carboxamide, 7-(chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)-

参考文献

1. Choi M, et al. Virus Genes. 2013 Dec;47(3):395-407.

Anguizole (HCV NS4B inhibitor)

生物&药学活性

物理化学性质&存储条件

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Anguizole (HCV NS4B inhibitor)

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物理化学性质&存储条件

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