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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-Angoline
Angoline

Chemical Structure : Angoline

CAS No.: 21080-31-9

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Angoline (6-Methoxyldihydrochelerythrine)

货号: PC-24072Not For Human Use, Lab Use Only.

Angoline is a potent and selective inhibitor of IL6/STAT3 signaling pathway with IC50 of 11.56 uM, inhibits STAT3 phosphorylation and its target gene expression, also is an inhibitor of MORC2 protein, significantly kills the TNBC cells by blocking cell cycle and inducing apoptosis.

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10 mg ￥1180 In stock
25 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

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Angoline is a potent and selective inhibitor of IL6/STAT3 signaling pathway with IC50 of 11.56 uM, inhibits STAT3 phosphorylation and its target gene expression, also is an inhibitor of MORC2 protein, significantly kills the TNBC cells by blocking cell cycle and inducing apoptosis.

物理化学性质&存储条件

分子量 379.41
分子式 C22H21NO5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,2,13-Trimethoxy-12-methyl-12,13-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine

参考文献

1. Jiawei Liu, et al. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.

2. Su X, et al. Mater Today Bio. 2025 Jan 19;31:101497. 

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