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首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB-Andrographolide
Andrographolide

Chemical Structure : Andrographolide

CAS No.: 5508-58-7

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Andrographolide (Andrographis)

货号: PC-28518Not For Human Use, Lab Use Only.

Andrographolide is a diterpene lactone isolated from Cymbopogon schoenanthus, inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation, exhibits broad-spectrum antiviral properties.

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1 g ￥1180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Andrographolide is a diterpene lactone isolated from Cymbopogon schoenanthus, inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation, exhibits broad-spectrum antiviral properties.

物理化学性质&存储条件

分子量 350.46
分子式 C20H30O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S,E)-4-Hydroxy-3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethylidene)dihydrofuran-2(3H)-one

参考文献

1. Zhai ZJ, et al. Br J Pharmacol. 2014 Feb;171(3):663-75.

2. Gupta S, et al. Arch Virol. 2017 Mar;162(3):611-623.

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