Andamertinib | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : Andamertinib

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Andamertinib (PLB1004, PLB-1004)

货号: PC-24110Not For Human Use, Lab Use Only.

Andamertinib (PLB1004, PLB-1004) is a potent, selective and irreversible inhibitor of EGFR exon 20 insertion mutations with IC50 values ranging from 25.67-316.6 nM.

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生物&药学活性

Andamertinib (PLB1004, PLB-1004) is a potent, selective and irreversible inhibitor of EGFR exon 20 insertion mutations with IC50 values ranging from 25.67-316.6 nM.
PLB1004 also potently targets classical EGFR mutations ExDel19, L858R and T790M with a high degree of selectivity over wild-type EGFR.

物理化学性质&存储条件

分子量	568.68
分子式	C31H36N8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-methoxy-2-[4-(3-methoxyazetidin-1-yl)piperidin-1-yl]-5-{[6-(1 methyl-1H-indazol-5-yl)pyrimidin-4-yl]amino}phenyl)prop-2-enamide

参考文献

1. Jinji Yang, et al. Cancer Res (2023) 83 (8_Supplement): CT102.

2. Patent CN108707139 A.

Andamertinib (PLB1004, PLB-1004)

生物&药学活性

物理化学性质&存储条件

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Andamertinib (PLB1004, PLB-1004)

生物&药学活性

物理化学性质&存储条件

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