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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aromatase-Anastrozole
Anastrozole

Chemical Structure : Anastrozole

CAS No.: 120511-73-1

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Anastrozole (Arimidex, ZD1033, ZD-1033)

货号: PC-28394Not For Human Use, Lab Use Only.

Anastrozole (Arimidex, ZD1033) is a potent, highly selective, nonsteroidal aromatase inhibitor with IC50 of 15 nM for human placental aromatase, causes regression of breast carcinomas by reducing estrogen production via inhibition of aromatase (estrogen synthetase).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Anastrozole (Arimidex, ZD1033) is a potent, highly selective, nonsteroidal aromatase inhibitor with IC50 of 15 nM for human placental aromatase, causes regression of breast carcinomas by reducing estrogen production via inhibition of aromatase (estrogen synthetase).

物理化学性质&存储条件

分子量 293.37
分子式 C17H19N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,2'-(5-((1H-1,2,4-triazol-1-yl)methyl)-1,3-phenylene)bis(2-methylpropanenitrile)

参考文献

1. Geisler J, et al. Br J Cancer. 1996 Oct;74(8):1286-91.

2. Buzdar A, et al. J Clin Oncol. 1996 Jul;14(7):2000-11.

3. Dukes M, et al. J Steroid Biochem Mol Biol. 1996 Jul;58(4):439-45.

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