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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-Amt-87
Amt-87

Chemical Structure : Amt-87

CAS No.: 1609019-52-4

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Amt-87 (Amt87)

货号: PC-35630Not For Human Use, Lab Use Only.

Amt-87 is a HIV latency-reversal agent that reactivates latent HIV at the transcriptional level, promotes phosphorylation of CDK9 T-loop at Thr186.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Amt-87 is a HIV latency-reversal agent that reactivates latent HIV at the transcriptional level, promotes phosphorylation of CDK9 T-loop at Thr186.
    Amt-87 induces P-TEFb dissociation from 7SK snRNP and promotes Tat-SEC formation on HIV-1 LTR, dissociates P-TEFb from 7SK snRNP and promotes Tat-SEC formation at the HIV-1 promoter.
    Amt-87 synergizes with prostratin and JQ1 to reverse HIV latency and reactivate viral transcription.

    物理化学性质&存储条件

    分子量 492.612
    分子式 C30H36O6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-3-(5-(adamantan-1-yl)-2,4-bis(methoxymethoxy) phenyl)-1-(2-hydroxy-5-methylphenyl)prop-2-en-1-one

    参考文献

    1. Wu J, et al. Sci Rep. 2017 Sep 6;7(1):10657.

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