Amsilarotene (TAC-101) | RARα inhibitor | Probechem Biochemicals

Chemical Structure : Amsilarotene

CAS No.: 125973-56-0

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Amsilarotene (TAC-101, TAC101, Am 555S)

货号: PC-20433Not For Human Use, Lab Use Only.

Amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity, shows selective affinity for RARα with binding Ki of 2.4 nM.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

Amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity, shows selective affinity for RARα with binding Ki of 2.4 nM.
Amsilarotene inhibits retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent kinase (CDK) inhibitors, resulting in cell cycle arrest.
Amsilarotene also causes a cytotoxic decline in cyclin A and thymidylate synthase expression.
Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells.

物理化学性质&存储条件

分子量	385.61
分子式	C20H27NO3Si2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[3,5-Bis(trimethylsilyl) benzamido] benzoic acid

参考文献

1. Rizvi NA, et al. J Clin Oncol. 2002 Aug 15;20(16):3522-32.

2. Sakukawa R, et al. Oncol Res. 1998;10(6):287-93.

Amsilarotene (TAC-101, TAC101, Am 555S)

生物&药学活性

物理化学性质&存储条件

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Amsilarotene (TAC-101, TAC101, Am 555S)

生物&药学活性

物理化学性质&存储条件

参考文献

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