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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-NURR1 (NR4A2)-Amodiaquine
Amodiaquine

Chemical Structure : Amodiaquine

CAS No.: 86-42-0

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Amodiaquine (Amodiaquin)

货号: PC-20771Not For Human Use, Lab Use Only.

Amodiaquine (Amodiaquin, AQ) is an antimalarial agent and nuclear receptor Nurr1 (NR4A2) agonist, specifically binds to Nurr1-LBD (ligand binding domain) with EC50 of 20 uM.

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1 g ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Amodiaquine (Amodiaquin, AQ) is an antimalarial agent and nuclear receptor Nurr1 (NR4A2) agonist, specifically binds to Nurr1-LBD (ligand binding domain) with EC50 of 20 uM.
Amodiaquine suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
Amodiaquine significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake.
Amodiaquine exhibits neuroprotective effect in rat PC12 cells.
Amodiaquine also is a potent inhibitor of histamine N-methyltransferase protects mice from Propionibacterium acnes (P. acnes)-primed and lipopolysaccharide (LPS)-induced hepatitis.

物理化学性质&存储条件

分子量 355.87
分子式 C20H22ClN3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((7-chloroquinolin-4-yl)amino)-2-((diethylamino)methyl)phenol

参考文献

1. Chun-Hyung Kim, et al. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61.

2. Keita Kinoshita, et al. J Neuroimmunol. 2019 May 15;330:48-54.

3. Akira Yokoyama, et al. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84.

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