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首页-小分子抑制剂&激动剂-NF-κB Pathway-IκB kinase (IKK)-Amlexanox
Amlexanox

Chemical Structure : Amlexanox

CAS No.: 68302-57-8

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Amlexanox (AA-673)

货号: PC-20619Not For Human Use, Lab Use Only.

Amoxanox (AA-673) is a high affinity, specific inhibitor of IKKε and TBK1 with IC50 of 1-2 uM for both, without effect on IKKα or IKKβ.

规格 价格 库存 数量
100 mg ￥980 In stock
500 mg ￥1980 In stock
1 g ￥2880 In stock
5 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Amoxanox (AA-673) is a high affinity, specific inhibitor of IKKε and TBK1 with IC50 of 1-2 uM for both, without effect on IKKα or IKKβ.
Amoxanox (AA-673) reduces leukotriene D4- and platelet-activating factor-induced bronchoconstriction in guinea pigs, strongly suggesting an antagonistic activity against slow reacting substance of anaphylaxis.
Amoxanox (AA-673) is an approved small-molecule therapeutic presently used in the clinic to treat aphthous ulcers and asthma.
Amoxanox (AA-673) increases phosphorylation of TBK1 on Ser172 in 3T3-L1 adipocytes, and blocks polyinosinic:polycytidylic acid (poly I:C)-stimulated phosphorylation of interferon responsive factor-3 (IRF3), a presumed substrate of IKKε and TBK1.
Amoxanox (AA-673) (25 mg/kg, daily gavage) prevents and reverses diet-induced or genetic obesity, improves insulin sensitivity and glucose tolerance in obese mice.
Amoxanox (AA-673) reverses hepatic steatosis, reduces chronic adipose tissue inflammation and promotes energy expenditure in adipose tissue in obese mice.

物理化学性质&存储条件

分子量 298.30
分子式 C16H14N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(C1=C(N)N=C2C(C(C3=CC(C(C)C)=CC=C3O2)=O)=C1)O

参考文献

1. T Saijo, et al. Int Arch Allergy Appl Immunol. 1985;77(3):315-21.

2. Zhang Y, et al. Sci Rep. 2015 Sep 4;5:13575.

3. Reilly SM, et al. Nat Med. 2013 Mar;19(3):313-21.

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