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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Aryl hydrocarbon Receptor (AhR)-Aminoflavone
Aminoflavone

Chemical Structure : Aminoflavone

CAS No.: 165179-35-1

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Aminoflavone (NSC-686288, NSC686288)

货号: PC-26119Not For Human Use, Lab Use Only.

Aminoflavone is a small molecule aryl hydrocarbon receptor (AhR) ligand, inhibits HIF-1alpha expression in an AhR-independent fashion, also inhibits α6-integrin expression and breast cancer sphere-initiating capacity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Aminoflavone is a small molecule aryl hydrocarbon receptor (AhR) ligand, inhibits HIF-1alpha expression in an AhR-independent fashion, also inhibits α6-integrin expression and breast cancer sphere-initiating capacity.

物理化学性质&存储条件

分子量 320.27
分子式 C16H11F3N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methylchromen-4-one

参考文献

1. Campbell PS, et al. J Cell Physiol. 2018 Jan;234(1):108-121.

2. Brantley E, et al. Cancer Lett. 2016 Jun 28;376(1):53-61.

3. Terzuoli E, et al. Cancer Res. 2010 Sep 1;70(17):6837-48.

4. Loaiza-Pérez AI, et al. Mol Cancer Ther. 2004 Jun;3(6):715-25.

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