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首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB inducing Kinase (NIK)-Amgen16
Amgen16

Chemical Structure : Amgen16

CAS No.: 1202761-92-9

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Amgen16 (Amgen 16)

货号: PC-35548Not For Human Use, Lab Use Only.

Amgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NF-kB activity is NIK-dependent.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Amgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NF-kB activity is NIK-dependent.
    IKKβ inhibitor MLX and dexamethasone enhances cytotoxicity of NIK-inhibitor in MMCLs with NIK-dependent NFkB activation. blocks BAFF induced NFkB activation in myeloma cells combined with IKKβ inhibitors.

    物理化学性质&存储条件

    分子量 354.838
    分子式 C19H19ClN4O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-((1-(2-amino-5-chloropyrimidin-4-yl)indolin-6-yl)ethynyl)cyclopentan-1-ol

    参考文献

    1. Demchenko YN, et al. Oncotarget. 2014 Jun 30;5(12):4554-66.

    2. Henry KL, et al. Sci Signal. 2018 Jul 31;11(541). pii: eaam8216.

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