Amelparib |CAS:1227156-72-0 Probechem Biochemicals

Chemical Structure : Amelparib

CAS No.: 1227156-72-0

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Amelparib (JPI-289;JPI289)

货号: PC-35437Not For Human Use, Lab Use Only.

Amelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.

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10 mg	￥8980	In stock
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生物&药学活性

Amelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.
Amelparib does not affect cell viability up to 1 mM in rat cortical neuronal cells.
Amelparib attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model.
JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke.

物理化学性质&存储条件

分子量	343.427
分子式	C19H25N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	10-ethoxy-8-[(morpholin-4-yl)methyl]-2,3,4,6-tetrahydrobenzo[h][1,6]naphthyridin-5(1H)-one

参考文献

1. Kim Y, et al. Clin Exp Pharmacol Physiol. 2017 Jun;44(6):671-679.

2. Kim Y, et al. Mol Neurobiol. 2018 Jan 30. doi: 10.1007/s12035-018-0910-6.

Amelparib (JPI-289;JPI289)

生物&药学活性

物理化学性质&存储条件

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Amelparib (JPI-289;JPI289)

生物&药学活性

物理化学性质&存储条件

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