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首页-小分子抑制剂&激动剂-GPCR-Opioid Receptor-Alvimopan dihydrate
Alvimopan dihydrate

Chemical Structure : Alvimopan dihydrate

CAS No.: 170098-38-1

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Alvimopan dihydrate (ADL 8-2698, LY246736)

货号: PC-45977Not For Human Use, Lab Use Only.

Alvimopan (ADL 8-2698, LY246736) dihydrate selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Alvimopan (ADL 8-2698, LY246736) dihydrate selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus.
Alvimopan prevents gastrointestinal effects of intravenous morphine without affecting analgesia; orally active.

物理化学性质&存储条件

分子量 460.5631
分子式 C25H36N2O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-, hydrate (1:2)

参考文献

1. Fukuda H, et al. Brain Res. 2006 Aug 2;1102(1):63-70.

2. Taguchi A, et al. N Engl J Med. 2001 Sep 27;345(13):935-40.

3. Schmidt WK. Am J Surg. 2001 Nov;182(5A Suppl):27S-38S.

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