Alvespimycin hydrochloride (17-DMAG) | HSP90 inhibitor

Chemical Structure : Alvespimycin hydrochloride

CAS No.: 467214-21-7

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Alvespimycin hydrochloride (17-DMAG, KOS-1022, NSC 707545)

货号: PC-42839Not For Human Use, Lab Use Only.

Alvespimycin hydrochloride (17-DMAG) is a potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM.

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25 mg	￥880	In stock
50 mg	￥1380	In stock
100 mg	￥2180	In stock
250 mg		Get quote

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生物&药学活性

Alvespimycin hydrochloride (17-DMAG) is a potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM.
17-DMAG also show comparable binding affinity for Grp94 with EC50 of 65 nM.
17-DMAG inhibits the migration and the extracellular matrix-invasiveness of HUVEC in vitro, also inhibits FGF-2 and VEGF-induced HUVEC proliferation and induces apoptosis.

物理化学性质&存储条件

分子量	653.2065
分子式	C32H49ClN4O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 50 mg/mL
Chemical Name/SMILES	Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-, hydrochloride (1:1)

参考文献

1. Bull EE, et al. Clin Cancer Res. 2004 Dec 1;10(23):8077-84.

2. Kaur G, et al. Clin Cancer Res. 2004 Jul 15;10(14):4813-21.

3. Ge J, et al. J Med Chem. 2006 Jul 27;49(15):4606-15.

Alvespimycin hydrochloride (17-DMAG, KOS-1022, NSC 707545)

生物&药学活性

物理化学性质&存储条件

参考文献

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Alvespimycin hydrochloride (17-DMAG, KOS-1022, NSC 707545)

生物&药学活性

物理化学性质&存储条件

参考文献

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