Alobresib (GS-5829) |CAS:1637771-14-2 Probechem Biochemicals

Chemical Structure : Alobresib

CAS No.: 1637771-14-2

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Alobresib (GS5829, GS-5829)

货号: PC-38148Not For Human Use, Lab Use Only.

GS-5829 (GS5829, Alobresib) is a novel potent, selective BET inhibitor.

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10 mg	￥1980	In stock
50 mg	￥4980	In stock
100 mg	￥7980	In stock
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1 g		Get quote

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生物&药学活性

GS-5829 (GS5829, Alobresib) is a novel potent, selective BET inhibitor.
GS-5829 dose-dependently induced apoptosis of CLL cells, 400 nM GS-5829 reduced the percentage of viable cells from 94.8% to 64.4%.
In XTT viability/proliferation assay, GS-5829 demonstrated more potency against MEC-1 CLL cells compared to JQ1 with IC50 of 46.4 nM.
GS-5829 inhibited CLL cell proliferation and induced leukemia cell apoptosis through deregulation of key signaling pathways, such as BLK, AKT, ERK1/2, and MYC.
GS-5829 also inhibited NF-κB signaling. GS-5829 significantly reduced c-Myc protein expression in ARK2 xenograft tumor samples, impaired USC-ARK2 xenograft tumor growth in vivo.

物理化学性质&存储条件

分子量	437.5
分子式	C26H23N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-cyclopropyl-5-(3,5-dimethyl-4-isoxazolyl)-α,α-di-2-pyridinyl-1H-benzimidazole-7-methanol

参考文献

1. Bonazzoli E, et al. Clin Cancer Res. 2018 Oct 1;24(19):4845-4853.

2. Kim E, et al. Leukemia. 2020 Jun;34(6):1588-1598.

Alobresib (GS5829, GS-5829)

生物&药学活性

物理化学性质&存储条件

参考文献

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Alobresib (GS5829, GS-5829)

生物&药学活性

物理化学性质&存储条件

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