Almorexant (ACT-078573) | OX1R/OX2R antagonist | Probechem Biochemicals

Chemical Structure : Almorexant

CAS No.: 871224-64-5

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Almorexant (ACT-078573, ACT078573)

货号: PC-42704Not For Human Use, Lab Use Only.

Almorexant (ACT-078573) is a potent, dual Orexin receptor OX1/OX2 antagonist with Ki of 1.3/0.17 nM for hOX1/hOX2 respectively.

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生物&药学活性

Almorexant (ACT-078573) is a potent, dual Orexin receptor OX1/OX2 antagonist with Ki of 1.3/0.17 nM for hOX1/hOX2 respectively.
Almorexant selectively inhibits the functional consequences of OX1 and OX2 receptor activation, such as intracellular Ca2+ mobilization.

物理化学性质&存储条件

分子量	512.5632
分子式	C29H31F3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2(1H)-Isoquinolineacetamide, 3,4-dihydro-6,7-dimethoxy-N-methyl-α-phenyl-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-, (αR,1S)-

参考文献

1. Malherbe P, et al. Mol Pharmacol. 2009 Sep;76(3):618-31.

2. Malherbe P, et al. Mol Pharmacol. 2010 Jul;78(1):81-93.

3. Li A, et al. J Physiol. 2010 Aug 1;588(Pt 15):2935-44.

Almorexant (ACT-078573, ACT078573)

生物&药学活性

物理化学性质&存储条件

参考文献

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Almorexant (ACT-078573, ACT078573)

生物&药学活性

物理化学性质&存储条件

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