Allitinib |CAS:897383-62-9 Probechem Biochemicals

Chemical Structure : Allitinib

CAS No.: 897383-62-9

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Allitinib (AST-1306;ALS1306)

货号: PC-60010Not For Human Use, Lab Use Only.

Allitinib (AST-1306, ALS1306)) is a novel potent, selective irreversible EGFR and HER2 inhibitor with IC50 of 0.5 and 3 nM in cell-free assays.

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Allitinib (AST-1306, ALS1306)) is a novel potent, selective irreversible EGFR and HER2 inhibitor with IC50 of 0.5 and 3 nM in cell-free assays; also inhibits ErbB4 (IC50=0.8 nM), displays >3,000-fold selectivity over other kinase families; exhibits strong antiproliferative effects on a panel of cancer cell lines, and potently suppresses tumor growth in vivo; orally available.

Solid Tumors

Phase 1 Clinical

物理化学性质&存储条件

分子量	448.877
分子式	C24H18ClFN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-[[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]amino]quinazolin-6-yl]acrylamide

参考文献

1. Xie H, et al. PLoS One. 2011;6(7):e21487.

2. Zhang H, et al. Cancer Lett. 2014 Aug 1;350(1-2):61-8.

3. Zhang J, et al. J Hematol Oncol. 2014 Mar 11;7:22.

Allitinib (AST-1306;ALS1306)

生物&药学活性

物理化学性质&存储条件

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Allitinib (AST-1306;ALS1306)

生物&药学活性

物理化学性质&存储条件

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