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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HBV-Alisporivir
Alisporivir

Chemical Structure : Alisporivir

CAS No.: 254435-95-5

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Alisporivir (Debio 025, DEBIO-025)

货号: PC-21261Not For Human Use, Lab Use Only.

Alisporivir (Debio 025, DEBIO-025) is a non-immunosuppressive cyclophilin inhibitor derived from cyclosporin A (CsA) with IC50 of 30 nM (CypD PPIase activity ), inhibits HCV replication in vitro more potently than CsA.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Alisporivir (Debio 025, DEBIO-025) is a non-immunosuppressive cyclophilin inhibitor derived from cyclosporin A (CsA) with IC50 of 30 nM (CypD PPIase activity ), inhibits HCV replication in vitro more potently than CsA.
Alisporivir (Debio 025, DEBIO-025) inhibits HCV subgenomic replicon replication in Huh 5-2 cells (luciferase assay) with EC50 of 0.27 ug/mL.
Alisporivir (Debio 025, DEBIO-025) selectively inhibits the replication of HIV-1 in a CD4+ cell line and in peripheral blood mononuclear cells, interferes with the function of CypA during the progression/completion of HIV-1 reverse transcription.
Alisporivir (Debio 025, DEBIO-025) also blocks SARS-CoV and MERS-CoV replication.

物理化学性质&存储条件

分子量 1216.66
分子式 C63H113N11O12
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,6S,9S,12R,15S,18S,21S,24S,27R,30S,33S)-25,30-diethyl-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18-triisobutyl-3,21,24-triisopropyl-1,4,7,10,12,15,19,27,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone

参考文献

1. Flisiak R, et al. Hepatology. 2008 Mar;47(3):817-26.

2. Inoue K, et al. Hepatology. 2007 Apr;45(4):921-8.

3. Ptak RG, et al. Antimicrob Agents Chemother. 2008 Apr;52(4):1302-17.

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