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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Renin-Aliskiren hemifumarate
Aliskiren hemifumarate

Chemical Structure : Aliskiren hemifumarate

CAS No.: 173334-58-2

Aliskiren hemifumarate (CGP 60536;CGP60536B;SPP 100)

货号: PC-42906Not For Human Use, Lab Use Only.

Aliskiren (CGP60536B) hemifumarate is a first-in-class, potent and highly selective, direct renin inhibitor with IC50 of 0.6 nM.

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25 mg ¥780 In stock
50 mg ¥1180 In stock
100 mg ¥1880 In stock
250 mg Get quote
1 g Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Aliskiren (CGP60536B) hemifumarate is a first-in-class, potent and highly selective, direct renin inhibitor with IC50 of 0.6 nM.
Aliskiren shows no significant inhibition on Cathepsin D, Cathepsin E, Pepsin and HIV-1 peptidase (> 50 uM); orally bioactive.

物理化学性质&存储条件

分子量 1219.589
分子式 C64H110N6O16
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-, (2E)-2-butenedioate (2:1)

参考文献

1. Wood JM, et al. Biochem Biophys Res Commun. 2003 Sep 5;308(4):698-705.

2. Desjarlais M, et al. Atherosclerosis. 2015 Oct;242(2):450-60.

3. Jumar A, et al. J Hypertens. 2015 Dec;33(12):2491-9.

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