Aldometanib (LXY-05-029)

Chemical Structure : Aldometanib

CAS No.: 2904601-67-6

加入收藏

货号: PC-49381Not For Human Use, Lab Use Only.

Aldometanib (LXY-05-029) is a selective small molecule inhibitor of aldolase (ALDOA) with IC50 of 50 uM in in vitro enzymatic assays, Aldometanib (5 nM) is sufficient to activate AMPK inside cells.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Aldometanib (LXY-05-029) is a selective small molecule inhibitor of aldolase (ALDOA) with IC50 of 50 uM in in vitro enzymatic assays, Aldometanib (5 nM) is sufficient to activate AMPK inside cells.
Aldometanib displays a Kd value of 20 uM in surface plasmon resonance (SPR) assays.
Aldometanib selectively activates the lysosomal pool of AMPK in cells.
Aldometanib blocked FBP by directly occupying the active centre of aldolase through conjugation to Lys230, mutation of Arg43 to alanine largely blocked the effects of aldometanib in aldolase inhibition as well as AMPK activation.
Aldometanib did not show any considerable inhibition (inhibitory rate >30%) on kinome screening assay.
Aldometanib activates AMPK through the lysosomal pathway without causing elevation of AMP/ADP, unless high doses are used.
Acute aldometanib administration decreased fasting blood glucose and improved glucose tolerance in normoglycaemic mice.
Aldometanib decreased fat mass, induced browning and elevated EE in HFD-induced obese mice, alleviated liver fibrosis in NASH mice.
Aldometanib extended lifespan in C. elegans via the lysosomal pathway.

物理化学性质&存储条件

分子量	593.459
分子式	C27H43Cl2IN2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2,6-dichlorobenzyl)-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide

参考文献

1. Chen-Song Zhang, et al. Nat Metab. 2022 Oct 10. doi: 10.1038/s42255-022-00640-7.