Alchemix (ZP281M) |CAS:281189-60-4 Probechem Biochemicals

Chemical Structure : Alchemix

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Alchemix (ZP281M)

货号: PC-61356Not For Human Use, Lab Use Only.

Alchemix (ZP281M) is a dual action as an alkylating agent and topoisomerase inhibitor with potent activity against anthracycline- and cisplatin-resistant tumor cancer.

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生物&药学活性

Alchemix (ZP281M) is a dual action as an alkylating agent and topoisomerase inhibitor with potent activity against anthracycline- and cisplatin-resistant tumor cancer.
Alchemix (ZP281M) shows excellent antitumor activity in Adriamycin-resistant (2780AD) and cisplatin-resistant cell lines (IC50=19 nM) in vitro and in vivo.
Alchemix (ZP281M) induces cell death independently of ATM and p53.

物理化学性质&存储条件

分子量	509.428
分子式	C24H30Cl2N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((2-(bis(2-chloroethyl)amino)ethyl)amino)-4-((2-(dimethylamino)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione

参考文献

1. Pors K, et al. Mol Cancer Ther. 2003 Jul;2(7):607-10.

2. Pors K, et al. J Med Chem. 2004 Mar 25;47(7):1856-9.

3. Thomas A, et al. Oncogene. 2015 Jun;34(25):3336-48.

Alchemix (ZP281M)

生物&药学活性

物理化学性质&存储条件

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Alchemix (ZP281M)

生物&药学活性

物理化学性质&存储条件

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