Akt activator SC79 | Akt activator | Probechem Biochemicals

Chemical Structure : Akt activator SC79

CAS No.: 305834-79-1

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Akt activator SC79 (SC-79)

货号: PC-45548Not For Human Use, Lab Use Only.

SC-79 is a unique specific Akt activator, binds to the PH domain of Akt and inhibits Akt membrane translocation, but paradoxically activates Akt in the cytosol.

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10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

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生物&药学活性

SC-79 is a unique specific Akt activator, binds to the PH domain of Akt and inhibits Akt membrane translocation, but paradoxically activates Akt in the cytosol.
SC-79 induces the p-Akt (Ser473) expression and significantly increases the expression of Bcl-2 and p-GSK-3β (Ser9), decreases the protein levels of Bax, cytoplasm cytochrome C, and cleaved caspase-3.
SC-79 augments neuronal survival in mouse model for ischemic strok.

物理化学性质&存储条件

分子量	364.7803
分子式	C17H17ClN2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4H-1-Benzopyran-4-acetic acid, 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-, ethyl ester

参考文献

1. Jo H, et al. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-6.

2. Zhang D, et al. ACS Chem Neurosci. 2016 Jun 15;7(6):710-8.

3. Hao S, et al. Molecules. 2016 Mar 10;21(3):325.

Akt activator SC79 (SC-79)

生物&药学活性

物理化学性质&存储条件

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Akt activator SC79 (SC-79)

生物&药学活性

物理化学性质&存储条件

参考文献

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