AhR antagonist SG-02 | AhR antagonist | Probechem Biochemicals

Chemical Structure : AhR antagonist SG-02

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AhR antagonist SG-02 (SG-02, SG02)

货号: PC-22422Not For Human Use, Lab Use Only.

AhR antagonist SG-02 is a potent utrophin modulator /upregulator and functions as an aryl hydrocarbon (AhR) antagonist with excellent binding affinity (Kd=41.68 nM).

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生物&药学活性

AhR antagonist SG-02 is a potent utrophin modulator /upregulator and functions as an aryl hydrocarbon (AhR) antagonist with excellent binding affinity (Kd=41.68 nM).
AhR antagonist SG-02 upregulates utrophin mRNA up to 2.11-fold and protein level up to 2.7-fold at 800 nM, validated through qRT-PCR and Western blot analysis.
SG-02 also exhibits an increased fusion of C2C12 myoblast cells into mature myotubes.
AhR antagonist SG-02 is a potential oral bioavailable drug candidate that could treat the universal DMD population by utrophin upregulation.

物理化学性质&存储条件

分子量	331.37
分子式	C16H14FN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-fluorobenzyl)-6-(methylsulfonyl)quinazolin-2-amine

参考文献

1. Surojit Ghosh, et al. J Med Chem. 2024 May 21. doi: 10.1021/acs.jmedchem.4c00398.

AhR antagonist SG-02 (SG-02, SG02)

生物&药学活性

物理化学性质&存储条件

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AhR antagonist SG-02 (SG-02, SG02)

生物&药学活性

物理化学性质&存储条件

参考文献

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