AgrC inhibitor CP-20 | AgrC inhibitor | Probechem Biochemicals

Chemical Structure : AgrC inhibitor CP-20

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AgrC inhibitor CP-20 (S. aureus agr/ATP synthase inhibitor)

货号: PC-26393Not For Human Use, Lab Use Only.

AgrC inhibitor CP-20 is a specific small molecule inhibitor of quorum sensing receptor AgrC in Staphylococcus aureus with IC50 of 0.93 uM in group-I S. aureus transcriptional reporter assays.

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生物&药学活性

AgrC inhibitor CP-20 is a specific small molecule inhibitor of quorum sensing receptor AgrC in Staphylococcus aureus with IC50 of 0.93 uM in group-I S. aureus transcriptional reporter assays, also inhibits ATP synthase.

CP-20 decreases cellular ATP in a dose-dependent manner (IC50 = 4.40 uM).

CP-20 facilitates more efficient clearance of S. aureus by murine macrophages than genetic inactivation of either agr or ATP synthase alone.

AgrC inhibitor CP-20 could potentially target the AgrC sensor domain in both S. epidermidis and S. aureus (∼30–40% conserved across species).

CP-20 to completely inhibit P3 transcription (IC50 = 16 μM), strongly suggesting it targets either AgrC or AgrA.

CP-20 does not inhibit agr by directly preventing AgrA from binding to DNA, while directly inhibits AgrC autophosphorylation.

物理化学性质&存储条件

分子量	418.91
分子式	C18H15ClN4O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-chlorophenyl)-2-(thiophene-3-carboxamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxamide

参考文献

1. Polaske TJ, et al. J Am Chem Soc. 2026 Mar 11;148(9):9199-9204.

AgrC inhibitor CP-20 (S. aureus agr/ATP synthase inhibitor)

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AgrC inhibitor CP-20 (S. aureus agr/ATP synthase inhibitor)

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