AgrA inhibitor F19 |CAS:1532534-68-1 Probechem Biochemicals

Chemical Structure : AgrA inhibitor F19

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AgrA inhibitor F19

货号: PC-35816Not For Human Use, Lab Use Only.

AgrA inhibitor F19 is a small-molecule AgrA inhibitor that act as antivirulence agent against Gram-positive pathogens, blocks staphylococcal transcription factor AgrA from binding to its promoter and inhibits toxin and virulence factor transcription.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
250 mg		Get quote
1 g		Get quote

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生物&药学活性

AgrA inhibitor F19 is a small-molecule AgrA inhibitor that act as antivirulence agent against Gram-positive pathogens, blocks staphylococcal transcription factor AgrA from binding to its promoter and inhibits toxin and virulence factor transcription.
AgrA inhibitor F19 binds to C-terminal DNA-binding domain (AgrA_C) from Staphylococcus epidermidis with an affinity of 2.7 uM.
AgrA inhibitor F19 potentiates β-lactam antibiotics in a MRSA wound model.

物理化学性质&存储条件

分子量	370.489
分子式	C23H30O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-hexyl-2,4-dihydroxyphenyl)-2-(4-isopropylphenoxy)ethan-1-one

参考文献

1. Greenberg M, et al. Sci Rep. 2018 Oct 1;8(1):14578.

2. Khodaverdian V, et al. Antimicrob Agents Chemother. 2013 Aug;57(8):3645-52.