Chemical Structure : Afuresertib hydrochloride
CAS No.:
1047645-82-8
Afuresertib hydrochloride
(GSK 2110183 hydrochloride, GSK2110183 hydrochloride, LAE002 hydrochloride)
货号: PC-44665Not For Human Use, Lab Use Only.
Afuresertib (GSK2110183) hydrochloride potent, selective, ATP-competitive pan-AKT inhibitor with biochemical IC50 of 0.08/2/2.6 nM for AKT1/2/3.
| 规格 | 价格 | 库存 | 数量 |
| 5 mg | ￥980 | In stock | |
| 10 mg | ￥1480 | In stock | |
| 25 mg | ￥2580 | In stock | |
| 50 mg | ￥3980 | In stock | |
| 100 mg | | Get quote | |
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
Select Batch:
生物&药学活性
Afuresertib (GSK2110183) hydrochloride potent, selective, ATP-competitive pan-AKT inhibitor with biochemical IC50 of 0.08/2/2.6 nM for AKT1/2/3.
Afuresertib (GSK2110183) also inhibits PKA (IC50=1.3 nM) and AKT1 E17K mutant (IC50=0.2 nM), selective over PKC, PKG isoforms and p70S6K.
Afuresertib (GSK2110183) is orally bioactive.
物理化学性质&存储条件
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分子量
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463.7841
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分子式
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C18H18Cl3FN4OS
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20 °C 12 个月; 4°C 6 个月
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- 配置液
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-80 °C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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DMSO: ≥ 52 mg/mL
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Chemical Name/SMILES
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2-Thiophenecarboxamide, N-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-, hydrochloride (1:1)
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参考文献
1. Dumble M, et al. PLoS One. 2014 Jun 30;9(6):e100880.
2. Spencer A, et al. Blood. 2014 Oct 2;124(14):2190-5.
3. Arceci RJ, et al. Pediatr Blood Cancer. 2017 May;64(5).
