Aficamten (CK-3773274, CK-274)

Chemical Structure : Aficamten

CAS No.: 2364554-48-1

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货号: PC-38077Not For Human Use, Lab Use Only.

Aficamten (CK-3773274, CK-274) is a novel next-generation cardiac myosin inhibitor (IC50 =1.4 uM) for treatment of hypertrophic cardiomyopathy.

规格	价格	库存
5 mg	￥1780	In stock
10 mg	￥2780	In stock
25 mg	￥4580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Aficamten (CK-3773274, CK-274) is a novel next-generation cardiac myosin inhibitor (IC50 =1.4 uM) for treatment of hypertrophic cardiomyopathy.
Aficamten (CK-274) provides a projected human half-life appropriate for once a day dosing, reaching steady state within two weeks, has no substantial CYP induction or inhibition in preclinical assessment and demonstrates a wide therapeutic window in vivo with a clear PK/PD relationship.

物理化学性质&存储条件

分子量	337.38
分子式	C18H19N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-

参考文献

1. Chuang C, et al. J Med Chem. 2021 Oct 14;64(19):14142-14152.