Adomeglivant (LY-2409021)

Chemical Structure : Adomeglivant

CAS No.: 1488363-78-5

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货号: PC-45745Not For Human Use, Lab Use Only.

Adomeglivant (LY-2409021) is a potent, selective, orally active, small-molecule antagonist of human glucagon receptor with Ki of 6.66 nM.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

Adomeglivant (LY-2409021) is a potent, selective, orally active, small-molecule antagonist of human glucagon receptor with Ki of 6.66 nM.
Adomeglivant (LY-2409021) displays >200-fold selectivity over related receptors.
Adomeglivant (LY-2409021) exhibits robust glucose-lowering in response to daily oral administration in an ob/ob mouse model of type 2 diabetes mellitus.

物理化学性质&存储条件

分子量	555.6277
分子式	C32H36F3NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 5.3 mg/mL
Chemical Name/SMILES	β-Alanine, N-[4-[(1S)-1-[[4'-(1,1-dimethylethyl)-2,6-dimethyl[1,1'-biphenyl]-4-yl]oxy]-4,4,4-trifluorobutyl]benzoyl]-

参考文献

1. Kelly RP, et al. Diabetes Obes Metab. 2015 Apr;17(4):414-22.

2. Grover S, et al. BMC Bioinformatics. 2014;15 Suppl 16:S13.

3. Kazda CM, et al. Diabetes Obes Metab. 2017 Aug;19(8):1071-1077.