Adjudin |CAS:252025-52-8 Probechem Biochemicals

Chemical Structure : Adjudin

CAS No.: 252025-52-8

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Adjudin (AF-2364, AF2364)

货号: PC-45593Not For Human Use, Lab Use Only.

Adjudin (AF-2364) is a potent analog of lonidamine known to disrupt germ cell adhesion, a potential candidate for male contraceptive development.

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10 mg	￥1680	In stock
25 mg	￥2780	In stock
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生物&药学活性

Adjudin (AF-2364) is a potent analog of lonidamine known to disrupt germ cell adhesion, a potential candidate for male contraceptive development.
Adjudin (AF-2364) targets actin filament bundles at the apical ES, blocks the expression of PAR6 and 14-3-3 (also known as PAR5).
Adjudin (AF-2364) also induces apoptosis in cancer cells through a Caspase-3-dependent pathway.
Adjudin (AF-2364) inhibited LPS-induced IL-6 release and IL-6, IL-1β, TNF-α expression in BV2 microglial cells.

物理化学性质&存储条件

分子量	335.188
分子式	C15H12Cl2N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 34 mg/mL
Chemical Name/SMILES	1H-Indazole-3-carboxylic acid, 1-[(2,4-dichlorophenyl)methyl]-, hydrazide

参考文献

1. Cheng CY, et al. Spermatogenesis. 2011 Oct;1(4):291-297.

2. Xie QR, et al. Biochem Pharmacol. 2013 Feb 1;85(3):345-55.

3. Shao J, et al. J Neuroimmunol. 2013 Jan 15;254(1-2):83-90.

Adjudin (AF-2364, AF2364)

生物&药学活性

物理化学性质&存储条件

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Adjudin (AF-2364, AF2364)

生物&药学活性

物理化学性质&存储条件

参考文献

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