AdipoRon

Chemical Structure : AdipoRon

CAS No.: 924416-43-3

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货号: PC-73200Not For Human Use, Lab Use Only.

AdipoRon is an orally active, small-molecule adiponectin receptor (AdipoR) agonist, binds to both AdipoR1 and AdipoR2 wit Kd of 1.8 and 3.1 uM, respectively.

规格	价格	库存
25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg	￥2680	In stock
200 mg	￥3980	In stock
1 g		Get quote

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生物&药学活性

AdipoRon is an orally active, small-molecule adiponectin receptor (AdipoR) agonist, binds to both AdipoR1 and AdipoR2 wit Kd of 1.8 and 3.1 uM, respectively.
AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed a high-fat diet.
AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet.
AdipoRon attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings.
AdipoRon inhibits leptin induced pSTAT3 and in vivo pancreatic tumor growth.

物理化学性质&存储条件

分子量	428.52
分子式	C27H28N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Okada-Iwabu M, et al. Nature. 2013 Nov 28;503(7477):493-9.

2. Zhang Y, et al. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E275-82.

3. Fairaq A, et al. Pharmacol Res. 2017 May;119:289-302.

4. Messaggio F, et al. Oncotarget. 2017 Aug 3;8(49):85378-85391.

AdipoRon

生物&药学活性

物理化学性质&存储条件

参考文献

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AdipoRon

生物&药学活性

物理化学性质&存储条件

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