AdipoAI

Chemical Structure : AdipoAI

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货号: PC-73201Not For Human Use, Lab Use Only.

AdipoAI is a novel small molecule APN receptor (AdipoR, adiponectin receptor) agonist.

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生物&药学活性

AdipoAI is a novel small molecule APN receptor (AdipoR, adiponectin receptor) agonist.
AdipoAI (5 uM) inhibits the mRNA expression of pro-inflammatory cytokines IL-6 and IL1-β in LPS-stimulated RAW 264.7 macrophages, exhibits stronger inhibitory effects than AdipoRon.
AdipoAI decreases inflammation in DIO mice, protects against LPS-induced endotoxemia.
AdipoAI inhibits NF-κB and p38 MAPK signalling pathways, decreases c-Maf activation directly in LPS-induced macrophages.
AdipoR1 and APPL1 are involved in the anti-inflammatory effects of AdipoAI in macrophages.

物理化学性质&存储条件

分子量	493.000
分子式	C28H29ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(4-chlorobenzoyl)phenoxy)-N-(1-(4-methoxybenzyl)piperidin-4-yl)acetamide

参考文献

1. Qiu W, et al. Br J Pharmacol. 2021 Jan;178(2):280-297.

AdipoAI

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物理化学性质&存储条件

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AdipoAI

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物理化学性质&存储条件

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