Adavosertib (AZD-1775, MK-1775) | Wee1 inhibitor | Probechem Biochemicals

Chemical Structure : Adavosertib

CAS No.: 955365-80-7

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Adavosertib (AZD-1775, MK-1775, AZD1775, MK1775)

货号: PC-42770Not For Human Use, Lab Use Only.

Adavosertib (AZD-1775;MK-1775) is a potent and selective small-molecule inhibitor of Wee1 kinase with IC50 of 5.2 nM.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg	￥3980	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

Adavosertib (AZD-1775, MK-1775) is a potent and selective small-molecule inhibitor of Wee1 kinase with IC50 of 5.2 nM.
Adavosertib (AZD-1775, MK-1775) exhibits ATP-competitive and highly selective against other serine/threonine or tyrosine kinases.
Adavosertib (AZD-1775, MK-1775) inhibits phosphorylation of CDC2 at Tyr15 in cells;.
Adavosertib (AZD-1775, MK-1775) potentiates tumor growth inhibition in vivo.

物理化学性质&存储条件

分子量	500.5954
分子式	C27H32N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-

参考文献

1. Hirai H, et al. Mol Cancer Ther. 2009 Nov;8(11):2992-3000.

2. Hirai H, et al. Cancer Biol Ther. 2010 Apr 1;9(7):514-22.

3. Bridges KA, et al. Clin Cancer Res. 2011 Sep 1;17(17):5638-48.

Adavosertib (AZD-1775, MK-1775, AZD1775, MK1775)

生物&药学活性

物理化学性质&存储条件

参考文献

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Adavosertib (AZD-1775, MK-1775, AZD1775, MK1775)

生物&药学活性

物理化学性质&存储条件

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