Adaphostin | Bcr-Abl inhibitor | Probechem Biochemicals

Chemical Structure : Adaphostin

CAS No.: 241127-58-2

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Adaphostin (AG 957 Adamantyl Ester, NSC 680410)

货号: PC-38592Not For Human Use, Lab Use Only.

Adaphostin (AG 957 Adamantyl Ester, NSC 680410) is a p210 Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 uM, induces apoptosis in T-lymphoblastic human leukemia cell lines with IC50 of 16.8-216.3 nM.

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25 mg	￥1380	In stock
100 mg	￥2980	In stock
200 mg	￥3980	In stock
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生物&药学活性

Adaphostin (AG 957 Adamantyl Ester, NSC 680410) is a p210 Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 uM, induces apoptosis in T-lymphoblastic human leukemia cell lines with IC50 of 16.8-216.3 nM.
Adaphostin decreased p210(bcr/abl) polypeptide levels in K562 cells, followed by caspase activation and accumulation of apoptotic cells.
Adaphostin down-regulated p210bcr/abl in K562 cells and inhibited granulocyte colony formation in CML specimens at lower concentrations without enhanced toxicity in normal progenitors.

物理化学性质&存储条件

分子量	393.5
分子式	C24H27NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Adamantyl 4-((2,5-dihydroxybenzyl)amino)benzoate

参考文献

1. Svingen PA, et al. Clin Cancer Res. 2000 Jan;6(1):237-49.

2. Mow BM, et al. Blood. 2002 Jan 15;99(2):664-71.

3. Avramis IA, et al. Cancer Chemother Pharmacol. 2002 Dec;50(6):479-89.

Adaphostin (AG 957 Adamantyl Ester, NSC 680410)

生物&药学活性

物理化学性质&存储条件

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Adaphostin (AG 957 Adamantyl Ester, NSC 680410)

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物理化学性质&存储条件

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