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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aminopeptidase-Actinonin
Actinonin

Chemical Structure : Actinonin

CAS No.: 13434-13-4

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Actinonin ((-)-Actinonin)

货号: PC-20620Not For Human Use, Lab Use Only.

Actinonin is an isolated antibiotic and shown to be an inhibitor of aminopeptidase M, inhibits enkephalin-degrading enzymes from guinea-pig striatum (enkephalin-aminopeptidase), striatal membrane neutral endopeptidase and soluble dipeptidylaminopeptidase in rat whole brain homogenate with IC50 of 0.39, 5.6 and 1.1 uM, respectively.

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10 mg ￥1580 In stock
25 mg ￥2880 In stock
100 mg ￥7980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Actinonin is an isolated antibiotic and shown to be an inhibitor of aminopeptidase M, inhibits enkephalin-degrading enzymes from guinea-pig striatum (enkephalin-aminopeptidase), striatal membrane neutral endopeptidase and soluble dipeptidylaminopeptidase in rat whole brain homogenate with IC50 of 0.39, 5.6 and 1.1 uM, respectively.
Actinonin administered intracisternally (i.cist., 50 micrograms) or intraperitoneally (i.p., 100 mg/kg), potentiated the analgesic action of met-enkephalin (50 micrograms i.cist.). analgesia by a tail-flick test.
Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with Ki of 0.28 nM. inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively.
Actinonin inhibits cell growth in various human tumor cell lines. The IC50 of 4, 6.9, 12.8, 16.6, 27.4, 15.7 and 49.3 μM for Raji cells, MDA-MB-468 cells,PC3 cells, SK-LC-19 cells, Hela cells, HT-1080 cells and AL67 cells, respectively.
Actinonin is active against Gram-positive bacteria, including S. aureus (MIC value of 8-16 µg/mL), Streptococcus pyogenes (MIC value of 8 µg/mL) and Streptococcus epidermidis (MIC value of 2-4 µg/mL).

物理化学性质&存储条件

分子量 385.50
分子式 C19H35N3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(N[C@H](C(N1[C@H](CO)CCC1)=O)C(C)C)[C@H](CCCCC)CC(NO)=O

参考文献

1. Umezawa H, et al. J Antibiot (Tokyo). 1985 Nov;38(11):1629-30.

2. Hachisu M, et al. Eur J Pharmacol. 1987 May 7;137(1):59-65.

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