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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA/RNA Synthesis-Actinomycin D
Actinomycin D

Chemical Structure : Actinomycin D

CAS No.: 50-76-0

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Actinomycin D (Dactinomycin, Actinomycin IV)

货号: PC-45350Not For Human Use, Lab Use Only.

Actinomycin D is a chemotherapy agent that has the ability to inhibit transcription, binds to DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase, inhibits DNA repair with IC50 of 0.42 uM.

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生物&药学活性

Actinomycin D is a chemotherapy agent that has the ability to inhibit transcription, binds to DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase, inhibits DNA repair with IC50 of 0.42 uM.
Actinomycin D can also interfere with DNA replication.
Actinomycin D leads to the accumulation of transcriptionally active p53 in the nucleus of HeLa, CaSki, and SiHa cells.

物理化学性质&存储条件

分子量 1255.417
分子式 C62H86N12O16
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 27 mg/mL; DMSO: 250 mg/mL (Need ultrasonic); Methanol: 6.2 mg/mL; Methanol: 20 mg/mL (Need ultrasonic); H2O: < 12.5 mg/mL
Chemical Name/SMILES

Actinomycin D

参考文献

1. Hietanen S, et al. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8501-6.

2. Sobell HM. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31.

3. Uberti EM, et al. Gynecol Oncol. 2009 Dec;115(3):476-81.

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