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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-Acriflavine
Acriflavine

Chemical Structure : Acriflavine

CAS No.: 8048-52-0

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Acriflavine (Acriflavin, Acriflavinium chloride)

货号: PC-72814Not For Human Use, Lab Use Only.

Acriflavine (Acriflavin) is a topical antiseptic that found to be a potent papain-like protease (PLpro) inhibitor, inhibits SARS-CoV-2 and other betacoronaviruses.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Acriflavine (Acriflavin) is a topical antiseptic that found to be a potent papain-like protease (PLpro) inhibitor, inhibits SARS-CoV-2 and other betacoronaviruses.
Acriflavine blocks the PLpro catalytic pocket in an unexpected binding mode, inhibits viral replication at nanomolar concentration in cellular models, in vivo in mice and ex vivo in human airway epithelia, with broad range activity against SARS-CoV-2 and other betacoronaviruses.
Acriflavine efficiently inhibited MERS-CoV (IC50 = 21 nM) and HCoV-OC43 (IC50= 105 nM).

物理化学性质&存储条件

分子量 259.73
分子式 C14H14ClN3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3,6-Diamino-10-methylacridinium chloride-3,6-acridinediamine mixt

参考文献

1. Napolitano V, et al. Cell Chem Biol. 2022 Jan 11:S2451-9456(21)00513-4.

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